Spectrum of Picamilon Neuropharmacological
Activity in Animals Under Experiment

[Article in Russian]

Institute of Pharmacology, 
B, Baltiyskaya st., Moscow, 125315, USSR 

Abstract

During experiment in different animals it has been revealed that picamilon with in the range of doses which don't evoke the depression of CNS has a pronounced anxiolytic effect and is free of myorelaxation typical to benzodiazepine related tranquilizers.  Picamilon was shown to recover working capacity following physical and psychic tiredness and improve reflectory activity disturbed by alcohol in addition to its stimulating and awakening effect in barbiturate narcosis and potentiation of opiate antinociceptive action.  There are reported the first results of pharmacological studies of picamilon obtained in neuro-pharmacological screening tests and LD50 in mice, under per os and i.p. administration of the drug.  

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